葡萄糖 D-Galactose

概况

葡萄糖化学式
  • 中文名称

    口服葡萄糖; L-(-)-甘露糖; L-(-)-葡萄糖; DL-甘露糖; 阿罗糖; L-乳糖; L(-)-阿洛糖; D-无水葡萄糖; 葡萄糖; D-阿洛糖; L-(-)-塔洛糖; (2S,3R,4S,5R)-2,3,4,5,6-五羟基己醛; D-艾杜糖; L-(-)-无水葡萄糖; D-(+)-葡萄糖; 甘露糖; D(+)-阿卓糖; D-吡喃半乳糖; 无水葡萄糖; D-甘露糖; D-(+)-阿洛糖; 右旋糖; D-葡糖; L-(-)-半乳糖; L-葡萄糖; 水解乳糖; D(+)半乳糖; D-(+)-塔罗糖; D-(+)-甘露糖; L-(-)-艾杜糖; L(-)-塔洛糖; D-(+)-塔洛糖; D-吡喃葡萄糖; L-阿卓糖; L-阿洛糖; L-(+)-古洛糖; D-(+)-吡喃葡萄糖; D(+)-麦芽糖; 艾杜糖; L-半乳糖; D-葡萄糖; a-D-吡喃半乳糖; 分解乳糖; L(-)-甘露糖; L(-)-阿卓糖; D-(+)-半乳糖; α-D-葡萄糖; D-半乳糖; α-D-(+)-塔罗糖; Alpha-D-(+)-塔罗糖; D-阿卓糖; 阿洛糖; D-古罗糖D-古洛糖; D-古洛糖; 古洛糖; 半乳糖; L-(-)-水解乳糖; D-葡萄糖-UL-14C; D-葡萄糖-1-3H(N)

  • 英文名称

    D-Galactose; aldehydo-D-glucose; aldehydo-L-glucose; aldehydo-D-talose; aldehydo-L-talose; L-galactose; α-D-mannose; L-(-)-mannose; aldehydo-L-gulose; D-altrose; (2R,3S,4S,5S)-2,3,4,5,6-pentahydroxyhexanal; L-Allose; D-gulopyranose; glucose; MANNOSE; D-idose; D,L-glucose; α-D-galactose; L-Idose - Aqueous solution; aldehydo-D-allose; D,L-Glc; DL-Glucose; Glucose; D-GLUCOSE-UL-14C; D-GLUCOSE-[1-3H(N)]; D-glucose

  • 化学式

    C6H12O6

  • 分子量

    180.16

  • 分类属性

    芳香醛及脂肪醛脂肪醇开链化合物六碳多糖和糖苷

  • 类药性

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编码系统

物化性质

  • 物理描述 Physical Description

    Watery odorless colorless liquid. Denser than water and soluble in water. Hence sinks in and mixes with water. (USCG, 1999)

  • 颜色/状态 Color Form

    Colorless crystals or white granular powder

  • 气味 Odor

    Odorless

  • 味道 Taste

    Sweet

  • 沸点 Boiling Point

    greater than 212 °F at 760 mm Hg (USCG, 1999)

  • 熔点 Melting Point

    146 °C

  • 溶解度 Solubility

    In water, 5.46X10+5 mg/L at 30 °C, 4.79X10+5 mg/L at 20 °C

  • 密度 Density

    1.2 at 68 °F (est.) (USCG, 1999)

  • 蒸汽压力 Vapor Pressure

    8.0X10-14 mm Hg at 25 °C /extrapolated from a higher solid-phase temperature range/

  • 稳定性/保质期 Stability Shelf Life

    Stable under recommended storage conditions.

  • 自燃温度 Autoignition Temperature

    Not flammable (USCG, 1999)

  • 分解 Decomposition

    When heated to decomposition it emits acrid smoke and irritating fumes.

  • 解离常数 Dissociation Constants

    pKa = 12.92 at 0 °C

  • 其他实验性质 Other Experimental Properties

    Crystals from hot ethanol or water; MP 146 °C. Specific optical rotation: +112.2 deg to +52.7 deg (c = 10 in water) at 25 °C/D. pH of 0.5 molar aq solution: 5.9. Density of water solution wt/vol: 5% = 1.019 at 17.5 °C/17.5 °C. Index of refraction: 10% Solution 1/3479 at 20 °C/D. One gram dissolves in 1.1 mL water at 25 °C; in 0.8 mL at 30 °C; in 0.41 mL at 50 °C; ... in 120 mL methanol at 20 °C. Very sparingly soluble in and alcohol, ether, acetone; soluble in hot glacial acetic acid, pyridine, aniline. /alpha-Glucose, anhydrous/

  • 辛醇/水分配系数 LogP

    log Kow = -3.00

  • 旋光度 Optical Rotation

    SPECIFIC OPTICAL ROTATION: +52.7 (WATER) @ 20 °C/D; MAX ABSORPTION (WATER): 282 NM (LOG E= 1.2); SADTLER REFERENCE NUMBER: 5455 (IR, PRISM); 199 (IR, GRATING)

  • 氢离子浓度指数 pH

    pH of 0.5 molar aqueous solution = 5.9 /alpha-glucose/

计算性质

  • 辛醇/水分配系数 LogP

    -2.9

  • 重原子数 Heavy atoms count

    12

  • 可旋转键数 Rotatable bond count

    5

  • 环数 Number of rings

    0

  • sp3杂化的碳原子比例 Carbon bond saturation (Fsp3)

    0.833

  • 拓扑面积 Polar surface area (Å)

    118

  • 氢给体数 Hydrogen bond donors count

    5

  • 氢受体数 Hydrogen bond acceptors count

    6

分类

ADME

吸收、分配和排泄
代谢
吸收、分配和排泄

Polysaccharides can be broken down into smaller units by pancreatic and intestinal glycosidases or intestinal flora. Sodium-dependent glucose transporter SGLT1 and GLUT2 (SLC2A2) play predominant roles in intestinal transport of glucose into the circulation.[A19395] SGLT1 is located in the apical membrane of the intestinal wall while GLUT2 is located in the basolateral membrane, but it was proposed that GLUT2 can be recruited into the apical membrane after a high luminal glucose bolus allowing bulk absorption of glucose by facilitated diffusion.[A19400] Oral preparation of glucose reaches the peak concentration within 40 minutes and the intravenous infusions display 100% bioavailability.[A19406]

展开
代谢

Glucose can be renally excreted.[A19408]

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安全信息

  • 危险品标志

    Xi;F;R;Xn

  • WGK Germany

    3;1

  • 危险品运输编号

    UN 2910 7;NONH for all modes of transport

  • 海关编码

    2912491000;29400000;29400090;2940000000;17023051

  • RTECS号

    LZ6600000;LW5490000;LZ6610000

  • 安全说明
    S22;S24/25;S26;S36;S16;S27;S36/37/39;S36/37;S25;S53
  • 危险类别码
    R36/37/38;R11

SDS

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