- 热门化合物 :
- 物质11
- 2-丙炔-1-醇
- americium,trifluoride
- neptunium hexafluoride
- neptunium tetrachloride
L-脯氨酸 L-proline
概况
物化性质
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物理描述 Physical Description
Solid
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颜色/状态 Color Form
Flat needles from alcohol + ether; prisms from water
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气味 Odor
Odorless
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味道 Taste
Sweet
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熔点 Melting Point
220-222 °C, decomposes
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溶解度 Solubility
Solubility in 100 mL of water: 127 g at 0 °C; 162 g at 25 °C; 206.7 g at 50 °C; 239 g at 65 °C
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密度 Density
1.064 at 24 °C
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蒸汽压力 Vapor Pressure
3.02X10-8 mm Hg at 25 °C (est)
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稳定性/保质期 Stability Shelf Life
Stable under recommended storage conditions.
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分解 Decomposition
When heated to decomposition it emits toxic vapors of /nitrogen oxides/.
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解离常数 Dissociation Constants
pK1 = 1.99 /carboxylic/; pK2 = 10.60 /amine/
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其他实验性质 Other Experimental Properties
Monohydrate, crystals. MP 190 °C (when anhydrous, decomposes at 205 °C). Soluble in water, alcohol; sparingly soluble in acetone, chloroform, benzene; insoluble in ether /DL-Proline/
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辛醇/水分配系数 LogP
-2.54
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旋光度 Optical Rotation
Specific optical rotation: -85.0 at 23.4 °C/D; -52.6 at 20 °C/D (0.50N hydrochloric acid, 0.58%); -93.9 deg at 20 °C/D (0.6N potassium hydroxide, 2.4%)
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碰撞截面 Collision Cross Section
125.1 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]
计算性质
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辛醇/水分配系数 LogP
-2.5
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重原子数 Heavy atoms count
8
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可旋转键数 Rotatable bond count
1
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环数 Number of rings
1
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sp3杂化的碳原子比例 Carbon bond saturation (Fsp3)
0.8
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拓扑面积 Polar surface area (Å)
49.3
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氢给体数 Hydrogen bond donors count
2
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氢受体数 Hydrogen bond acceptors count
3
ADME
L-proline is absorbed from the gastrointestinal tract. Ingested dietary protein is denatured in the stomach due to low pH. Denaturing and unfolding of the protein makes the chain susceptible to proteolysis. Up to 15% of dietary protein may be cleaved to peptides and amino acids by pepsins in the stomach. In the duodenum and small intestine digestion continues through hydrolytic enzymes (e.g. trypsin, chymotrypsins, elastase, carboxypeptidase). The resultant mixture of peptides and amino acids is then transported into the mucosal cells by specific carrier systems for amino acids and for di- and tripeptides. The products of digestion are rapidly absorbed. Like other amino acids L-proline is absorbed from ileum and distal jejeunum.
Absorbed peptides are further hydrolyzed resulting in free amino acids which are secreted into the portal blood by specific carrier systems in the mucosal cell. Alternatively they are metabolized within the cell itself. Absorbed amino acids pass into the liver where a portion of the amino acids are used. The remainder pass through into the systemic circulation and are utilized by the peripheral tissue. L-proline is actively transported across the intestine from mucosa to serosal surface. The mechanism of absorption is that of the ion gradient. All L-amino acids are absorbed by Na+dependant, carrier mediated process. This transport is energy dependant by ATP. Plasma L-proline concentrations in normal subjects are reported to be ca. 168 uM/L +/- 60 mM/L with plasma samples collected from healthy volunteers after an overnight fast. As with most nutrients, plasma concentration of L-proline is subject to homeostasis. A number of hormones (e.g., thyroid hormone, catecholamines, and growth hormone) may affect plasma AA levels in diseases. However, in the physiologic state, their influence is probably marginal. However, there is the counter-regulatory hormone system with cortisol and glucagon which influences the blood level of amino acids involved in gluconeogenesis, such as L-proline.
安全信息
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危险品标志
Xn；Xi
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WGK Germany
3
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危险品运输编号
UN 2910 7
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海关编码
2933990090
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RTECS号
TW3584000
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安全说明S24/25
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危险类别码R22；R36/37/38
热门化合物
