8-羟基喹啉 8-Hydroxyquinoline

概况

8-羟基喹啉化学式
  • 中文名称

    8-羟基喹啉; 8-羟基氮杂萘; 8-喹啉醇; 8-氢氧化喹啉; 喹啉醇

  • 英文名称

    8-Hydroxyquinoline; 8-quinolinol; quinolin-8-ol; oxine

  • 化学式

    C9H7NO

  • 分子量

    145.16

  • 分类属性

    脂肪醇多碳吡啶喹啉

  • 类药性

    点击查看

编码系统

物化性质

  • 物理描述 Physical Description

    8-hydroxyquinoline appears as white to off-white or faintly yellow crystalline powder. Phenolic odor. (NTP, 1992)

  • 颜色/状态 Color Form

    White crystals or white crystalline powder

  • 气味 Odor

    Phenolic odor

  • 沸点 Boiling Point

    267.0 °C

  • 熔点 Melting Point

    75.5 °C

  • 溶解度 Solubility

    In water, 556 mg/l @ 20 °C

  • 密度 Density

    1.034 @ 20 °C

  • 蒸汽压力 Vapor Pressure

    1.66X10-3 mm Hg @ 25 °C

  • 稳定性/保质期 Stability Shelf Life

    DARKENS WHEN EXPOSED TO LIGHT.

  • 分解 Decomposition

    WHEN HEATED TO DECOMP EMITS HIGHLY TOXIC FUMES OF /NITROGEN OXIDES/.

  • 解离常数 Dissociation Constants

    pKa 5.017; Ka 1.21X10-6 at 20 °C

  • 保留指数 Kovats Retention Index

    1326.3;1348.9;1339;1312

  • 其他实验性质 Other Experimental Properties

    Pale yellow, crystalline powder; slight saffron odor; burning taste; MP: 175-178 °C; freely sol in water; insol in ether; sol in about 100 parts glycerol; slightly sol in alcohol /8-Hydroxyquinoline sulfate/

  • 辛醇/水分配系数 LogP

    2.02 (LogP)

  • 酸度系数/解离常数 pKa

    5.017

  • 碰撞截面 Collision Cross Section

    123.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

  • 辛醇/水分配系数 LogP

    2

  • 重原子数 Heavy atoms count

    11

  • 可旋转键数 Rotatable bond count

    0

  • 环数 Number of rings

    2

  • sp3杂化的碳原子比例 Carbon bond saturation (Fsp3)

    0

  • 拓扑面积 Polar surface area (Å)

    33.1

  • 氢给体数 Hydrogen bond donors count

    1

  • 氢受体数 Hydrogen bond acceptors count

    2

分类

ADME

吸收、分配和排泄
代谢
吸收、分配和排泄

Oxyquinoline is excreted in both the primarily in the urine with some in the bile [A27146].

展开
代谢

IN RATS /MALE, DONRYU STRAIN, IV INJECTION/ 8-HYDROXYQUINOLINE WAS METABOLIZED TO GLUCURONIDE & SULFATE CONJUGATES. MORE 8-HYDROXYQUINOLINE GLUCURONIDE WAS EXCRETED IN URINE THAN 8-HYDROXYQUINOLINE SULFATE CONJUGATE. ONLY THE GLUCURONIDE CONJUGATE WAS EXCRETED IN BILE.

展开

晶体信息

安全信息

  • 危险品标志

    Xn

  • WGK Germany

    3

  • 危险品运输编号

    2811

  • 海关编码

    2933499090

  • 危险标志

    GHS07

  • RTECS号

    VC4200000

  • 安全说明
    S26;S45;S36/37/39
  • 危险类别码
    R22;R68;R36/37/38
  • 危险性描述
    H302

SDS

提供商 修订日期 查看
Accela ChemBio Inc 点击查看
COMBI-BLOCKS 2019-12-13 点击查看
Fisher Scientific 2018-01-18 点击查看
POCH 2005-03-26 点击查看
Science Lab 2013-05-21 点击查看
Sigma Aldrich 2021-12-17 点击查看
ThermoFisher 2020-02-14 点击查看
EMD Millipore 2014-10-15 点击查看
LabChem 2016-09-02 点击查看
GFS Chemicals 2015-05-19 点击查看
Sigma Aldrich 2021-10-27 点击查看
Fisher Scientific Company 点击查看
Fisher Scientific Company 点击查看
Fisher Scientific Company 点击查看
Fisher Scientific Company 点击查看
Fisher Scientific Company 点击查看